Hydrochloric Acid → (Imidazo[1,2-a]pyridin-5-yl)acetic acid

Participants

Reaction Conditions

Reaction Steps

To a stirring mixture of tert-butyl 2-(imidazo[1,2-a]pyridin-5-yl)acetate (200 mg) in HOAc (5 mL) was added 6N HCl (5 mL). The reaction mixture was warmed to 80° C. for 2 h. The crude product mixture was concentrated under reduced pressure and directly taken to the next reaction without further purification. Method[1], MS (ESI) 177.1 [M+H], Retention time=0.303 min.

Provenance & Evidence