Hydrochloric Acid → (Imidazo[1,2-a]pyridin-5-yl)acetic acid

HRID 2098104Notes

Reaction equation

HRID 2098104 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])=[CH:8][CH:7]=[CH:6][C:5]=12.Cl>CC(O)=O>[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([CH2:10][C:11]([OH:13])=[O:12])=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68783369HCID 68783369, compound

Product 1

HCID 18936841(Imidazo[1,2-a]pyridin-5-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a stirring mixture of tert-butyl 2-(imidazo[1,2-a]pyridin-5-yl)acetate (200 mg) in HOAc (5 mL) was added 6N HCl (5 mL). The reaction mixture was warmed to 80° C. for 2 h. The crude product mixture was concentrated under reduced pressure and directly taken to the next reaction without further purification. Method[1], MS (ESI) 177.1 [M+H], Retention time=0.303 min.

Workup

  1. concentrationThe crude product mixture was concentrated under reduced pressure
  2. customdirectly taken to the next reaction without further purification

Sources & evidence

ORD record
ord-9be97da9c0da47cc83e25f1ef044e60b
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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