2-Chloro-3-nitrothiophene → 2-Methoxy-4-(3-nitrothiophen-2-yl)thiazole

HRID 2098119Notes

Reaction equation

HRID 2098119 reaction equation
[CH3:1][O:2][C:3]1[S:4][CH:5]=[C:6]([Sn](CCCC)(CCCC)CCCC)[N:7]=1.Cl[C:22]1[S:23][CH:24]=[CH:25][C:26]=1[N+:27]([O-:29])=[O:28]>>[CH3:1][O:2][C:3]1[S:4][CH:5]=[C:6]([C:22]2[S:23][CH:24]=[CH:25][C:26]=2[N+:27]([O-:29])=[O:28])[N:7]=1

Participants

3

Reactant 2

HCID 2201862-Chloro-3-nitrothiopheneHCID 27632642-Methoxy-4-(tributylstannyl)thiazole

Product 1

HCID 687557612-Methoxy-4-(3-nitrothiophen-2-yl)thiazole

Procedure

2-Methoxy-4-(3-nitrothiophen-2-yl)thiazole was prepared from 2-methoxy-4-(tributylstannyl)thiazole (1.0 g, 2.47 mmol) and 2-chloro-3-nitrothiophene (0.404 g, 2.47 mmol) according to protocol E. Retention time (min)=2.516, method [1], MS (ESI) 242.9 (M+H).

Sources & evidence

ORD record
ord-cd16429c3f3b4f1f81e013a38e4920a2
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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