2-(Thiazol-4-yl)thiophen-3-amine → HCID 68784811, compound

HRID 2098146Notes

Reaction equation

HRID 2098146 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]2[S:7][CH:8]=[CH:9][C:10]=2[NH2:11])[N:3]=[CH:2]1.[O:12]=[C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:19]=2)[N:14]1[CH2:27][C:28](O)=[O:29]>>[O:12]=[C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:23]([F:25])([F:24])[F:26])[CH:19]=2)[N:14]1[CH2:27][C:28]([NH:11][C:10]1[CH:9]=[CH:8][S:7][C:6]=1[C:4]1[N:3]=[CH:2][S:1][CH:5]=1)=[O:29]

Participants

3

Reactant 2

HCID 687553622-(Thiazol-4-yl)thiophen-3-amineHCID 687598572-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetic acid

Product 1

HCID 68784811HCID 68784811, compound

Procedure

The title compound was prepared from 2-(thiazol-4-yl)thiophen-3-amine and 2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetic acid according to protocol A. Retention time (min)=6.485, method [7], MS (ESI) 436.1 (M+H); 1H NMR (300 MHz, CD3C1) δ 11.32 (s, 1H), 8.51 (d, J=1.5 Hz, 1H), 8.04 (d, J=5.5 Hz, 1H), 7.92 (d, J=10.2 Hz, 1H), 7.90 (s, 1H), 7.80 (d, J=8.9 Hz, 1H), 7.50 (d, J=8.9 Hz, 1H), 7.22 (d, J=1.4 Hz, 1H), 7.20 (d, J=5.5 Hz, 1H), 7.03 (d, J=9.7 Hz, 1H), 5.23 (s, 2H).

Sources & evidence

ORD record
ord-97ef9a72f01f43fcac95db732cc34588
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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