HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tri-n-butylstannyl)oxazole → 5-Nitro-4-(oxazol-2-yl)thiophene-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tri-n-butylstannyl)oxazole | HCID 15486183 | — |
| Reactant | 4-Bromo-5-nitrothiophene-3-carbonitrile | HCID 59168810 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 5-Nitro-4-(oxazol-2-yl)thiophene-3-carbonitrile | HCID 68754451 | 18% |
Reaction Steps
The above titled compound (34 mg, 18%) was synthesized from 4-bromo-5-nitrothiophene-3-carbonitrile (203 mg, 0.87 mmol) and 2-tributylstannyloxazole (0.27 mL, 1.29 mmol), tetrakis(triphenylphosphine)palladium(0) (103 mg, 0.089 mmol) and copper(I) iodide (16 mg, 0.084 mmol) according to methods described herein. LCMS method [4], retention time=1.62 min; MS (ESI) 222.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-13e230e562224ec98e982828f9616428 |
| Source note | uspto-grants-2013_05 |