4-Methoxyphenylacetic Acid → HCID 46869150, compound

HRID 2098174Notes

Reaction equation

HRID 2098174 reaction equation
[N:1]1([C:6]2[S:7][CH:8]=[CH:9][C:10]=2[NH2:11])[CH:5]=[CH:4][CH:3]=[N:2]1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21](O)=[O:22])=[CH:16][CH:15]=1>>[N:1]1([C:6]2[S:7][CH:8]=[CH:9][C:10]=2[NH:11][C:21](=[O:22])[CH2:20][C:17]2[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=2)[CH:5]=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68781723HCID 68781723, compound

Product 1

HCID 46869150HCID 46869150, compound

Procedure

The title compound was prepared from 2-(1H-pyrazol-1-yl)thiophen-3-amine and 2-(4-methoxyphenyl)acetic acid using protocol B. The solution was directly purified by HPLC to yield N-(2-(1H-pyrazol-1-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide. Method [7] Retention time 5.22 min by HPLC (MH+ 314). 1H NMR (300 MHz, CDCl3) δ 9.94 (broad s, 1H), 8.00 (d, J=5.7 Hz, 1H), 7.61 (d, J=2.7 Hz, 1H), 7.39 (d, J=1.8 Hz, 1H), 7.27 (m, 2H), 6.94 (m, 3H), 6.35 (t, J=2.4 Hz, 1H), 3.87 (s, 3H), 3.71 (s, 2H).

Workup

  1. customThe solution was directly purified by HPLC

Sources & evidence

ORD record
ord-b2908931146e416ba1a35c5614a7e419
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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