Isopropanol → HCID 548005, compound
Reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].[CH:10]([OH:13])([CH3:12])[CH3:11]>>[CH3:11][C:10]([OH:13])([CH2:3][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:1])[CH3:12]Participants
Procedure
By reaction of α-methylstyrene with isopropanol under the conditions described in example 1, after multistage distillation, a mixture which 2-methyl-4-phenyl-2-pentanol (90.3 GC area %) was obtained. In a 300 mL autoclave, 27.7 g of this mixture were dissolved in 132.3 g of tetrahydrofuran, and 1.6 g of a catalyst according to preparation example 1 were initially charged in a catalyst basket. The autoclave was purged three times with nitrogen. This was followed by hydrogenation at 160° C. and hydrogen pressure 160 bar for 10 hours. The output was analyzed by means of gas chromatography (30 m column material DB1 ID: 0.25 mm, FD: 0.25 μm, 50° C.—5 min isothermal, −6° C./min 290° C.—219 min isothermal). The composition of the output after 10 h is reported in the table below.
Workup
- distillationafter multistage distillation
Sources & evidence
- ORD record
- ord-50aef429767b43b68e7ea211a0ee650d
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08450534B2
Reaction notes
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