HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → 5-(4-Pyridinyl)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 5-Bromo-1H-indole-2-carboxylic acid | HCID 252137 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(4-Pyridinyl)-1H-indole-2-carboxylic acid | HCID 58286528 | — |
Reaction Steps
A solution of 5-bromo-1H-indole-2-carboxylic acid (25 mg), PdCl2 HPNor2 (5 mg), K3PO4 (45 mg), 4-pyridylboronic acid (26 mg), dioxane (1 mL) and H2O (1 mL) was heated to 170° C. in a microwave for 2 h. The solution was passed thru a C18-SPE cartridge eluting with 3, 20, 60, and finally 95% CH3CN in H2O to yield the crude product. LCMS (m/z): 239.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450484B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-5a183b0913714c8a8faaca6ba8c46aae |
| Source note | uspto-grants-2013_05 |