Ammonium Hydroxide → HCID 25791201, compound

HRID 2098521Notes

Reaction equation

HRID 2098521 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:10][O:9]2)[CH:5]=[CH:6][CH:7]=1.[NH4+:11].[OH-]>N.CO>[NH2:11][CH2:10][C@H:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[OH:9]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 40582624HCID 40582624, compound

Product 1

HCID 25791201HCID 25791201, compound

Reagents, catalysts & solvents 1

HCID 21705897Ammonia methanolSolvent

Procedure

(S)-2-(3-Bromophenyl)oxirane was dissolved in 7N NH3/MeOH solution (5 mL) and aqueous NH4OH (25%, 5 mL) was added to the reaction mixture which was stirred at room temperature for 18 hrs. The reaction mixture was concentrated under reduced pressure to give (S)-2-amino-1-(3-bromophenyl)ethanol (0.801 g) which was used in the next step without purification.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f946cf50d51949e9a76ab0966ca62ad2
Source dataset
uspto-grants-2013_05
Patent number
US08450527B2

Reaction notes

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