Water → HCID 59593081, compound

HRID 2098641Notes

Reaction equation

HRID 2098641 reaction equation
[OH:1]OS([O-])=O.[K+].[NH:7]1[C:15]2[C:10](=[C:11]([C:16]3[N:17]=[C:18]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][CH2:37]4)[C:19]4[S:24][C:23]([C:25]5[CH:26]=[C:27]([S:31][CH2:32][C@H:33]([OH:35])[CH3:34])[CH:28]=[CH:29][CH:30]=5)=[CH:22][C:20]=4[N:21]=3)[CH:12]=[CH:13][CH:14]=2)[CH:9]=[N:8]1.[OH2:42]>CO>[NH:7]1[C:15]2[C:10](=[C:11]([C:16]3[N:17]=[C:18]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][CH2:37]4)[C:19]4[S:24][C:23]([C:25]5[CH:26]=[C:27]([S:31]([CH2:32][C@H:33]([OH:35])[CH3:34])(=[O:1])=[O:42])[CH:28]=[CH:29][CH:30]=5)=[CH:22][C:20]=4[N:21]=3)[CH:12]=[CH:13][CH:14]=2)[CH:9]=[N:8]1

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 67189843HCID 67189843, compound

Product 1

HCID 59593081HCID 59593081, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 322 mg of oxone in 4 mL H2O was added to a mixture of 132 mg of (R)-1-(3-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)phenylthio)propan-2-ol in 8 mL of methanol. The reaction mixture was stirred for 2 h. The mixture was filtered and the filtrate was evaporated. The product was purified by reverse phase HPLC to yield 3.8 mg of 135. MS (Q1) 536 (M)+

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe product was purified by reverse phase HPLC

Sources & evidence

ORD record
ord-2b03d36c2d6c434cb0905292fce700f1
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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