Hydrochloric Acid → HCID 86618384, compound

Participants

Reaction Steps

To a mixture of 3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)propionic acid ethyl ester (1 g) in methanol (30 mL) was added 1 N aqueous sodium hydroxide solution (10 mL). The reaction mixture was stirred at room temperature for 1 h and then acidified to pH 6 using 2 M aqueous hydrochloric acid. The product was then filtered and washed with water to give 3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-propionic acid as a greenish-yellow solid (612 mg).

Provenance & Evidence