Hydrochloric Acid → HCID 86618384, compound

HRID 2098655Notes

Reaction equation

HRID 2098655 reaction equation
C([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[S:15][C:14]2[C:13]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[N:12][C:11]([Cl:22])=[N:10][C:9]=2[CH:8]=1)C.[OH-].[Na+].Cl>CO>[Cl:22][C:11]1[N:12]=[C:13]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[C:14]2[S:15][C:7]([CH2:6][CH2:5][C:4]([OH:23])=[O:3])=[CH:8][C:9]=2[N:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86618383HCID 86618383, compound

Product 1

HCID 86618384HCID 86618384, compoundYield 66.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)propionic acid ethyl ester (1 g) in methanol (30 mL) was added 1 N aqueous sodium hydroxide solution (10 mL). The reaction mixture was stirred at room temperature for 1 h and then acidified to pH 6 using 2 M aqueous hydrochloric acid. The product was then filtered and washed with water to give 3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-propionic acid as a greenish-yellow solid (612 mg).

Workup

  1. filtrationThe product was then filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-8329f2de0e6d4c2c982959026c91475f
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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