反应详情

2-Chloro-6-(1-methyl-piperidin-4-ylidenemethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole in general procedure A. Purification on silica yielded 181. NMR: (CDCl3) 2.37 (3H,s); 2.55 (6H,m); 2.82 (2H,t,J=5.5 Hz); 3.93 (4H,t,J=4.8 Hz); 4.10 (4H,t,J=4.8 Hz); 6.44 (1H,s); 7.33 (1H,s); 7.51 (1H,s); 7.60 (1H,d,J=8.2 Hz); 8.28 (1H,d,J=7.1 Hz); 9.03 (1H,s); 10.25 (br s). M+H(447)

1. customPurification on silica