HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole → 2-(1H-indazol-4-yl)-6-((1-methylpiperidin-4-ylidene)methyl)-4-morpholinothieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole | HCID 45480186 | — |
| Reactant | 2-Chloro-6-(1-methyl-piperidin-4-ylidenemethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | HCID 86618399 | — |
| Product | 2-(1H-indazol-4-yl)-6-((1-methylpiperidin-4-ylidene)methyl)-4-morpholinothieno[3,2-d]pyrimidine | HCID 59592948 | — |
Reaction Steps
2-Chloro-6-(1-methyl-piperidin-4-ylidenemethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole in general procedure A. Purification on silica yielded 181. NMR: (CDCl3) 2.37 (3H,s); 2.55 (6H,m); 2.82 (2H,t,J=5.5 Hz); 3.93 (4H,t,J=4.8 Hz); 4.10 (4H,t,J=4.8 Hz); 6.44 (1H,s); 7.33 (1H,s); 7.51 (1H,s); 7.60 (1H,d,J=8.2 Hz); 8.28 (1H,d,J=7.1 Hz); 9.03 (1H,s); 10.25 (br s). M+H(447)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-81fd7660e4ef45d4aeadeb489c73d764 |
| Source note | uspto-grants-2013_05 |