反应详情

温度

100 °C

To a solution of 3-iodo-propane-1-sulfonic acid dimethylamide (600 mg) in DMF (10 mL) was added potassium phthalimide (590 mg) and the reaction heated at 100° C. for 16 h. After cooling to room temperature, the reaction was partitioned between dichloromethane (30 mL) and water (30 mL). The organic layer was washed with aqueous brine solution (3×30 mL), dried (MgSO4) and reduced in vacuo to give 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid dimethylamide as a white solid.

1. temperatureAfter cooling to room temperature
2. customthe reaction was partitioned between dichloromethane (30 mL) and water (30 mL)
3. washThe organic layer was washed with aqueous brine solution (3×30 mL)
4. dry with materialdried (MgSO4)