Hydrogen Bromide → 2-Bromo-1-(4-chlorophenyl)propan-1-one

Participants

Reaction Steps

To a mixture of 10.12 g of 4-chloropropiophenone, 0.1 ml of hydrobromic acid (48% aqueous solution) and 60 ml of acetic acid was added 3.1 ml of bromine at 0° C. under a nitrogen atmosphere, and stirred at room temperature for 1 hour. Thereafter, the reaction mixture was concentrated under reduced pressure, to obtain 14.34 g of 2-bromo-4′-chloropropiophenone.

Provenance & Evidence