Hydrogen Bromide → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 2099064Notes

Reaction equation

HRID 2099064 reaction equation
[CH3:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].[BrH:12].BrBr>C(O)(=O)C>[Br:12][CH:2]([CH3:1])[C:3]([C:5]1[CH:6]=[CH:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[O:4]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 226974'-ChloropropiophenoneHCID 24408Bromine

Product 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 10.12 g of 4-chloropropiophenone, 0.1 ml of hydrobromic acid (48% aqueous solution) and 60 ml of acetic acid was added 3.1 ml of bromine at 0° C. under a nitrogen atmosphere, and stirred at room temperature for 1 hour. Thereafter, the reaction mixture was concentrated under reduced pressure, to obtain 14.34 g of 2-bromo-4′-chloropropiophenone.

Workup

  1. concentrationThereafter, the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1c2176c8642442079a97047ef027a501
Source dataset
uspto-grants-2009_08
Patent number
US07569518B2

Reaction notes

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