Diethyl (ethoxymethylene)malonate → ST50846277

HRID 2099127Notes

Reaction equation

HRID 2099127 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(O[CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C>>[N:1]1([CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 694601,2,3,4-Tetrahydroquinoline

Product 1

HCID 258635ST50846277

Conditions

Temperature
130 °C

Procedure

A mixture of tetrahydroquinoline (13.32 g, 100 mmol) and diethyl ethoxymethylenemalonate (21.62 g, 100 mmol) is heated to 130° C. using a Dean-Stark apparatus. After 1 hour the reaction mixture was concentrated to give the title compound as a brown oil. ESMS m/z 304 (MH+).

Workup

  1. concentrationAfter 1 hour the reaction mixture was concentrated

Sources & evidence

ORD record
ord-a1fd2045ea8043baa35a5d5b62b8cf64
Source dataset
uspto-grants-2009_08
Patent number
US07569550B2

Reaction notes

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