HRID2099316

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1c(N2CC(C)NC(C)C2)c(F)cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3Cl)cn(CC(F)(F)F)c12

HCID76607220

未命名化合物

PRODUCTS

生成物

结构：COc1c(N2CC(C)NC(C)C2)c(F)cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3Cl)cn(CC(F)(F)F)c12.Cl

HCID86623862

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

6780 mg of the compound from Example 37A (contains 1 eq. of acetonitrile) are dissolved in 4.3 ml of 4N hydrogen chloride in dioxane, the solution is concentrated on a rotary evaporator and the residue is then dried under high vacuum. Yield: 6730 mg (quantitative).

WORKUP

后处理

concentrationthe solution is concentrated on a rotary evaporator
customthe residue is then dried under high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c015e53282c642839d5e7fc48d800917
来源数据集: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07569563B2
来源说明: uspto-grants-2009_08

反应 SMILES

[Cl:1][C:2]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[C:12]([O:28][CH3:29])[C:13]([N:20]3[CH2:25][CH:24]([CH3:26])[NH:23][CH:22]([CH3:27])[CH2:21]3)=[C:14]([F:19])[CH:15]=2)[N:10]([CH2:30][C:31]([F:34])([F:33])[F:32])[CH:9]=1)=[O:7]>Cl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[C:12]([O:28][CH3:29])[C:13]([N:20]3[CH2:21][CH:22]([CH3:27])[NH:23][CH:24]([CH3:26])[CH2:25]3)=[C:14]([F:19])[CH:15]=2)[N:10]([CH2:30][C:31]([F:33])([F:34])[F:32])[CH:9]=1)=[O:7]