Formaldehyde → HCID 11805402, compound

HRID 2099327Notes

Reaction equation

HRID 2099327 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1C(O)=O.[C:9]([O:13][CH2:14][CH3:15])(=[O:12])[CH:10]=[CH2:11].[CH2:16]=O>C1(C)C=CC=CC=1>[CH2:14]([O:13][C:9]([CH:10]1[CH:8]2[N:1]([CH2:2][CH2:6][CH2:7]2)[CH2:16][CH2:11]1)=[O:12])[CH3:15]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8821Ethyl AcrylateHCID 145742L-Proline

Product 1

HCID 11805402HCID 11805402, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of rac-proline (1.15 g), ethyl acrylate (1.20 g), toluene (80 ml) and paraformaldehyde (3.6 g) was heated to reflux for 3 hours. The mixture was concentrated and the residue was filtered through silica gel. The product with the molecular weight of 183.25 (C10H17NO2); MS (ESI): 184 (M+H+) was obtained in this way.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 hours
  3. concentrationThe mixture was concentrated
  4. filtrationthe residue was filtered through silica gel
  5. customMS (ESI): 184 (M+H+) was obtained in this way

Sources & evidence

ORD record
ord-dcb4c167ad074f4caef0f106fbb4cae9
Source dataset
uspto-grants-2009_08
Patent number
US07569583B2

Reaction notes

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