HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11685952, compound → HCID 11685951, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11685952 | HCID 11685952 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 11685951 | HCID 11685951 | 167.4% |
Reaction Steps
0.18 g of N-[8-(4-chloro-N-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}-D-phenylalanyl)-8-azabicyclo[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea is placed in 0.4 ml of 2N hydrochloric acid in diethyl ether. Trituration, rinsing with diethyl ether, and filter-drying of the precipitate obtained are carried out. 0.16 g of N-[8-(4-chloro-N-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}-D-phenylalanyl)-8-azabicyclo-[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea hydrochloride is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569582B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-d0820cb119924831973dc34733ce228f |
| Source note | uspto-grants-2009_08 |