HCID 11685952, compound → HCID 11685951, compound

HRID 2099359Notes

Reaction equation

HRID 2099359 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][C@H:7]([C:16]([N:18]2[CH:23]3[CH2:24][CH2:25][CH:19]2[CH2:20][CH:21]([N:26]([CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]2)[C:27]([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])=[O:28])[CH2:22]3)=[O:17])[NH:8][CH2:9][C@@H:10]2[CH2:14][C@@H:13]([OH:15])[CH2:12][NH:11]2)=[CH:4][CH:3]=1>Cl.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][C@H:7]([C:16]([N:18]2[CH:23]3[CH2:24][CH2:25][CH:19]2[CH2:20][CH:21]([N:26]([CH:34]2[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]2)[C:27]([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])=[O:28])[CH2:22]3)=[O:17])[NH:8][CH2:9][C@@H:10]2[CH2:14][C@@H:13]([OH:15])[CH2:12][NH:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 11685952HCID 11685952, compound

Product 1

HCID 11685951HCID 11685951, compoundYield 167.4%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

0.18 g of N-[8-(4-chloro-N-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}-D-phenylalanyl)-8-azabicyclo[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea is placed in 0.4 ml of 2N hydrochloric acid in diethyl ether. Trituration, rinsing with diethyl ether, and filter-drying of the precipitate obtained are carried out. 0.16 g of N-[8-(4-chloro-N-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}-D-phenylalanyl)-8-azabicyclo-[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea hydrochloride is obtained.

Workup

  1. washTrituration, rinsing with diethyl ether
  2. customfilter-drying of the precipitate
  3. customobtained

Sources & evidence

ORD record
ord-d0820cb119924831973dc34733ce228f
Source dataset
uspto-grants-2009_08
Patent number
US07569582B2

Reaction notes

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