Hydrochloric Acid → HCID 68831865, compound

Participants

Reaction Steps

0.12 g of N-(8-{4-chloro-N-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylmethyl]-D-phenylalanyl}-8-azabicyclo[3.2.1]oct-3-yl)-N-cyclohexyl-N′,N′-diethylurea is dissolved in 5 ml of dichloromethane and 0.4 ml of 4N hydrochloric acid in dioxane is added. After evaporation, the residue is taken up in diethyl ether, rinsing is carried out with diethyl ether and the precipitate obtained is filter-dried. 0.12 g of N-(8-{4-chloro-N-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylmethyl]-D-phenylalanyl}-8-azabicyclo[3.2.1]oct-3-yl)-N-cyclohexyl-N′,N′-diethylurea hydrochloride is obtained.

Provenance & Evidence