Hydrochloric Acid → HCID 68831865, compound

HRID 2099366Notes

Reaction equation

HRID 2099366 reaction equation
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][C@H:7]([C:20]([N:22]2[CH:27]3[CH2:28][CH2:29][CH:23]2[CH2:24][CH:25]([N:30]([CH:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)[C:31]([N:33]([CH2:36][CH3:37])[CH2:34][CH3:35])=[O:32])[CH2:26]3)=[O:21])[NH:8][CH2:9][C@H:10]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][NH:11]2)=[CH:4][CH:3]=1.Cl>ClCCl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C@H:7]([C:20]([N:22]2[CH:23]3[CH2:29][CH2:28][CH:27]2[CH2:26][CH:25]([N:30]([CH:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)[C:31]([N:33]([CH2:34][CH3:35])[CH2:36][CH3:37])=[O:32])[CH2:24]3)=[O:21])[NH:8][CH2:9][C@H:10]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][NH:11]2)=[CH:44][CH:45]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68829890HCID 68829890, compound

Product 1

HCID 68831865HCID 68831865, compoundYield 189.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

0.12 g of N-(8-{4-chloro-N-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylmethyl]-D-phenylalanyl}-8-azabicyclo[3.2.1]oct-3-yl)-N-cyclohexyl-N′,N′-diethylurea is dissolved in 5 ml of dichloromethane and 0.4 ml of 4N hydrochloric acid in dioxane is added. After evaporation, the residue is taken up in diethyl ether, rinsing is carried out with diethyl ether and the precipitate obtained is filter-dried. 0.12 g of N-(8-{4-chloro-N-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylmethyl]-D-phenylalanyl}-8-azabicyclo[3.2.1]oct-3-yl)-N-cyclohexyl-N′,N′-diethylurea hydrochloride is obtained.

Workup

  1. customAfter evaporation
  2. washrinsing
  3. customthe precipitate obtained
  4. customis filter-dried

Sources & evidence

ORD record
ord-398c8f0ddbf647a3a51fd442f5aeaf94
Source dataset
uspto-grants-2009_08
Patent number
US07569582B2

Reaction notes

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