HCID 59442734, compound → 3-Amino-N-methyl-5-(trifluoromethyl)benzamide

HRID 2099448Notes

Reaction equation

HRID 2099448 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[C:5]([C:12]([NH:14][CH3:15])=[O:13])[CH:4]=1.N1(C2C=C(C=C([N+]([O-])=O)C=2)C(NC)=O)CCOCC1>>[NH2:9][C:7]1[CH:6]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:16])[F:17])[CH:8]=1)[C:12]([NH:14][CH3:15])=[O:13]

Participants

3

Reactant 2

HCID 59442734HCID 59442734, compoundHCID 59631038HCID 59631038, compound

Product 1

HCID 574314533-Amino-N-methyl-5-(trifluoromethyl)benzamide

Procedure

Utilising the procedure described in Example 86e, but employing α,α,α-trifluoro-N-methyl-5-nitro-m-toluamide (Dean E. Welch, J. Med. Chem. (1969), 12, 299-303) in lieu of 3-(4-morpholinyl)-5-nitro-N-(methyl)-benzamide, afforded the title compound as a beige crystalline solid, m.p. 113-115° C.

Sources & evidence

ORD record
ord-5d650ab6dcb34828b0ea01ddd2a87c8d
Source dataset
uspto-grants-2009_08
Patent number
US07569566B2

Reaction notes

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