1,1-Dimethylethyl N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate → 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline

HRID 2099455Notes

Reaction equation

HRID 2099455 reaction equation
CC1N=CN(C2C=C(NC(=O)OC(C)(C)C)C=C(C(F)(F)F)C=2)C=1.[CH3:25][C:26]1[N:27]([C:31]2[CH:32]=[C:33]([NH:41]C(=O)OC(C)(C)C)[CH:34]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:36]=2)[CH:28]=[CH:29][N:30]=1>>[CH3:25][C:26]1[N:27]([C:31]2[CH:36]=[C:35]([C:37]([F:40])([F:38])[F:39])[CH:34]=[C:33]([NH2:41])[CH:32]=2)[CH:28]=[CH:29][N:30]=1

Participants

3

Reactant 2

HCID 592971031,1-Dimethylethyl N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamateHCID 86605432[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester

Product 1

HCID 667757113-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline

Procedure

Utilising the procedure described in Example 91d, but employing [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 92c) in lieu of [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a colourless crystalline solid, m.p. 127-131° C.

Sources & evidence

ORD record
ord-a295a0dae9ba408791efddeea0c1cf22
Source dataset
uspto-grants-2009_08
Patent number
US07569566B2

Reaction notes

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