HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate → 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate | HCID 59297103 | — |
| Reactant | [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester | HCID 86605432 | — |
| Product | 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline | HCID 66775711 | — |
Reaction Steps
Utilising the procedure described in Example 91d, but employing [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 92c) in lieu of [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a colourless crystalline solid, m.p. 127-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569566B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-a295a0dae9ba408791efddeea0c1cf22 |
| Source note | uspto-grants-2009_08 |