Lithium Hydroxide → HCID 178461282, compound

HRID 2099636Notes

Reaction equation

HRID 2099636 reaction equation
C[O:2][C:3]([C:5]1[S:6][C:7]([C:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=2)=[CH:8][C:9]=1[N:10]([C:17]([C@H:19]1[CH2:24][CH2:23][C@H:22]([CH3:25])[CH2:21][CH2:20]1)=[O:18])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4].[OH-].[Li+]>>[C:26]1([C:7]2[S:6][C:5]([C:3]([OH:4])=[O:2])=[C:9]([N:10]([C:17]([C@H:19]3[CH2:20][CH2:21][C@H:22]([CH3:25])[CH2:23][CH2:24]3)=[O:18])[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:8]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 178499262HCID 178499262, compound

Product 1

HCID 178461282HCID 178461282, compoundYield 89%

Procedure

The product from Step II (38 mg, 0.09 mmol) was hydrolysed with lithium hydroxide as previously described (example 3, step VIII) to give 32 mg (89%) of 5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-94815c29a5994813ae25103383af5511
Source dataset
uspto-grants-2009_08
Patent number
US07569600B2

Reaction notes

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