Trifluoroacetic acid → HCID 86595987, compound

HRID 2099714Notes

Reaction equation

HRID 2099714 reaction equation
C(OC(=O)[N:7]([CH:10]([CH3:33])[CH2:11][C:12]1[CH:32]=[CH:31][C:15]2[O:16][CH:17]([CH2:19][NH:20][C:21]([O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:22])[O:18][C:14]=2[CH:13]=1)[CH2:8][CH3:9])(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>ClCCl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[CH2:24]([O:23][C:21](=[O:22])[NH:20][CH2:19][CH:17]1[O:16][C:15]2[CH:31]=[CH:32][C:12]([CH2:11][CH:10]([NH:7][CH2:8][CH3:9])[CH3:33])=[CH:13][C:14]=2[O:18]1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70986654HCID 70986654, compound

Product 1

HCID 86595987HCID 86595987, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.58 g (3.3 mmol) of 2G in 10 mL of dichloromethane (distilled over CaH2) was added trifluoroacetic acid at room temperature, and the mixture was allowed to stir at room temperature for 30 minutes. The resulting reaction mixture was concentrated under reduced pressure to dryness and purified by silica gel column chromatography to give 1.6 g (3.3 mmol, 98%) of 2H as a colorless gum (M+H, 371).

Workup

  1. customThe resulting reaction mixture
  2. concentrationwas concentrated under reduced pressure to dryness
  3. custompurified by silica gel column chromatography
  4. customto give 1.6 g (3.3 mmol, 98%) of 2H as a colorless gum (M+H, 371)

Sources & evidence

ORD record
ord-23104da7624f4403950c88fb61a513d6
Source dataset
uspto-grants-2009_08
Patent number
US07569676B2

Reaction notes

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