Hydrogen Bromide → 3459-15-2

HRID 2099724Notes

Reaction equation

HRID 2099724 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:15]>ClCCl>[BrH:15].[NH2:14][CH:12]([CH3:13])[CH2:11][C:5]1[CH:4]=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 8423(+-)-3,4-Dimethoxyamphetamine

Product 1

HCID 773286983459-15-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2.0 g of 3A (2.01 mmol) was added 48% HBr, and the mixture was heated on a preheated oil bath for 3 hours under argon atmosphere. The reaction mixture was concentrated under reduced pressure to give thick oil. To the residue, 75 mL of dichloromethane was added and concentrated to dryness under reduced pressure. This was repeated four more times to give 2.3 g of 3B as light pink powder (M+H, 168).

Workup

  1. temperaturethe mixture was heated on a preheated oil bath for 3 hours under argon atmosphere
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto give thick oil
  4. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c10008242d2f4cd38e1538169d465d1d
Source dataset
uspto-grants-2009_08
Patent number
US07569676B2

Reaction notes

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