Hydrochloric Acid → 4-(7-methyl-1H-indazol-5-yl)-3-pyridin-2-yl-butyric acid

HRID 2099738Notes

Reaction equation

HRID 2099738 reaction equation
C([O:5][C:6](=[O:26])[CH2:7][CH:8]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1)[CH2:9][C:10]1[CH:11]=[C:12]2[C:16](=[C:17]([CH3:19])[CH:18]=1)[NH:15][N:14]=[CH:13]2)(C)(C)C.Cl>O1CCOCC1>[CH3:19][C:17]1[CH:18]=[C:10]([CH2:9][CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:7][C:6]([OH:26])=[O:5])[CH:11]=[C:12]2[C:16]=1[NH:15][N:14]=[CH:13]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 577945784-(7-Methyl-1H-indazol-5-yl)-3-pyridin-2-yl-butyric acid tert-butyl ester

Product 1

HCID 160374384-(7-methyl-1H-indazol-5-yl)-3-pyridin-2-yl-butyric acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a flask containing 4-(7-Methyl-1H-indazol-5-yl)-3-pyridin-2-yl-butyric acid tert-butyl ester (10 mg, 0.028 mmol) was added hydrogen chloride in dioxane (4 M, 0.8 mL). The suspension was stirred at room temperature overnight (LCMS indicated 2/3 conversion after 2 h). The reaction mixture was concentrated in vacuo to dryness. Dioxane (1 mL) was added and the mixture again concentrated to dryness. The residue was carried on without further characterization. MS (ESI) 296 (MH)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo to dryness
  2. additionDioxane (1 mL) was added
  3. concentrationthe mixture again concentrated to dryness

Sources & evidence

ORD record
ord-72f243d5d4f849749cff34b3db059852
Source dataset
uspto-grants-2009_08
Patent number
US07569578B2

Reaction notes

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