反应详情

温度

125 °C

tert-Butyl-1-(1H-imidazol-2-yl)-2-(7-methyl-2-[{2-[trimethylsilyl]ethoxy}methyl]-2H-indazol-5-yl)ethylcarbamate (25 mg, 0.53 mmol), 1-fluoro-2-nitrobenzene (14 mg, 0.13 mmol), and potassium carbonate (18.2 mg, 0.13 mmol) were combined in acetonitrile (1.0 mL) and heated via microwave at 125° C. for 30 h. The reaction was concentrated, dissolved in methylene chloride, and washed with water (2×), brine (2×), dried over sodium sulfate, and concentrated. Purification by column chromatography afforded 20.4 mg (65%).

1. concentrationThe reaction was concentrated
2. dissolutiondissolved in methylene chloride
3. washwashed with water (2×), brine (2×)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customPurification by column chromatography
7. customafforded 20.4 mg (65%)