反应详情

A suspension of (±)-methyl 2-(4-(8-fluoro-1,2-dihydro-2-oxoquinazolin-3(4H)-yl)piperidine-1-carboxamido)-3-(7-methyl-1H-indazol-5-yl)propanoate (0.4 g, 0.79 mmol) in 1:1 tetrahydrofuran/methanol (30 mL) at room temperature was treated with a solution of lithium hydroxide (83 mg, 2.5 equiv) in water (4 mL) and stirred at room temperature overnight. The solvents were evaporated and the pH was adjusted to ca. 1 with 1 N hydrochloric acid. The resulting white suspension was stored at 4° C. overnight and the product was collected by filtration, washed with a small amount of water, and dried in vacuo to afford 0.21 g (74%) as a white powder. Mass spec.: 495.06 (MH)+.

1. customThe solvents were evaporated
2. waitThe resulting white suspension was stored at 4° C. overnight
3. filtrationthe product was collected by filtration
4. washwashed with a small amount of water
5. customdried in vacuo
6. customto afford 0.21 g (74%) as a white powder