Sulfuric Acid → HCID 22285184, compound

HRID 2099853Notes

Reaction equation

HRID 2099853 reaction equation
S(=O)(=O)(O)O.[C:6](OC(=O)C)(=[O:8])[CH3:7].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([N+:28]([O-:30])=[O:29])=[C:25]([CH:27]=2)[NH2:26])=[CH:17][CH:16]=1>C(OCC)C>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([N+:28]([O-:30])=[O:29])=[C:25]([NH:26][C:6](=[O:8])[CH3:7])[CH:27]=2)=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 22285186HCID 22285186, compound

Product 1

HCID 22285184HCID 22285184, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
40 °C

Procedure

A catalytic amount of concentrated sulfuric acid was added dropwise to an acetic anhydride (55 ml) suspension of 5-(4′-methoxyphenyl)-2-nitroaniline (2.02 g), followed by 3 hours and 20 minutes stirring at 40° C. After cooling to room temperature, diethyl ether (200 ml) was added thereto and the precipitated powder was collected by filtration to obtain N-(4′-methoxy-4-nitrobiphenyl-3-yl)acetamide (596 mg).

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-c02e0a59307548da865b3627ee7e6a72
Source dataset
uspto-grants-2009_08
Patent number
US07569688B2

Reaction notes

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