Water → HCID 73068188, compound

HRID 2099926Notes

Reaction equation

HRID 2099926 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([O:24][CH2:25][CH:26]=[C:27]([Cl:29])[Cl:28])[CH:21]=[C:20]([Cl:30])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15](=O)[CH2:14][CH2:13][CH2:12]2.C([O-])(=O)C.[Na+].Cl.[CH3:37][O:38][NH2:39].O>C(O)C>[CH3:37][O:38][N:39]=[C:15]1[C:16]2[C:11](=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][O:4][C:3]3[C:2]([Cl:1])=[CH:23][C:22]([O:24][CH2:25][CH:26]=[C:27]([Cl:28])[Cl:29])=[CH:21][C:20]=3[Cl:30])=[CH:18][CH:17]=2)[CH2:12][CH2:13][CH2:14]1

Participants

6

Reactant 4

HCID 962WaterHCID 517045Sodium AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 86605425HCID 86605425, compound

Product 1

HCID 73068188HCID 73068188, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.24 g of 6-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-3,4-dihydro-2H-naphthalen-1-one, 0.23 g of sodium acetate and 0.23 g of O-methylhydroxylamine hydrochloride are stirred in 10 ml of ethanol at 50° C. for 18 hours. The reaction mixture is poured into water and extracted with ethyl acetate. After concentration of the organic phases and purification over silica gel, the title compound is obtained. M.p. 75-77° C.

Workup

  1. extractionextracted with ethyl acetate
  2. customAfter concentration of the organic phases and purification over silica gel

Sources & evidence

ORD record
ord-89b045d842854837b44b54b46ba807e7
Source dataset
uspto-grants-2009_08
Patent number
US07569727B2

Reaction notes

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