Hydrogen Bromide → HCID 11063219, compound

HRID 2099940Notes

Reaction equation

HRID 2099940 reaction equation
Br.C[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH2:11]2)=[CH:6][CH:5]=1>C(OC(=O)C)(=O)C>[OH:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH2:11]2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 119770503-(4-Methoxyphenyl)cyclohexanone

Product 1

HCID 11063219HCID 11063219, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

2.12 ml of 48% aqueous hydrobromic acid are added slowly to 1.28 g of 3-(4-methoxyphenyl)cyclohexanone in 6.4 ml of acetic anhydride. After 4 hours at reflux, the reaction mixture is poured into ice-water and extracted with diethyl ether. After concentration of the organic phase and purification over silica gel, 3-(4-hydroxyphenyl)cyclohexanone is obtained in the form of an oil.

Workup

  1. temperatureAfter 4 hours at reflux
  2. extractionextracted with diethyl ether
  3. customAfter concentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-da0548bd83d0456f861ce3064ddfed15
Source dataset
uspto-grants-2009_08
Patent number
US07569727B2

Reaction notes

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