O-Methylhydroxylamine hydrochloride → HCID 76608186, compound

HRID 2099942Notes

Reaction equation

HRID 2099942 reaction equation
[Cl:1][C:2]1[CH:25]=[C:24]([O:26][CH2:27][CH:28]=[C:29]([Cl:31])[Cl:30])[CH:23]=[C:22]([Cl:32])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][CH2:18][C:17](=O)[CH2:16]2)=[CH:11][CH:10]=1.Cl.[CH3:34][O:35][NH2:36]>N1C=CC=CC=1>[CH3:34][O:35][N:36]=[C:17]1[CH2:18][CH2:19][CH2:20][CH:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][O:4][C:3]3[C:22]([Cl:32])=[CH:23][C:24]([O:26][CH2:27][CH:28]=[C:29]([Cl:30])[Cl:31])=[CH:25][C:2]=3[Cl:1])=[CH:14][CH:13]=2)[CH2:16]1

Participants

4

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 86605428HCID 86605428, compound

Product 1

HCID 76608186HCID 76608186, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

109 mg of 3-(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-cyclohexanone and 21 mg of O-methylhydroxylamine hydrochloride are stirred in 5 ml of pyridine at 85° C. for 3 hours. The reaction mixture is concentrated and the residue is stirred with tert-butyl methyl ether and 0.5N hydrochloric acid. After concentration of the organic phase and purification over silica gel, the title compound is obtained in the form of a colourless oil.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customAfter concentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-31a62b8409844306be90633d46315558
Source dataset
uspto-grants-2009_08
Patent number
US07569727B2

Reaction notes

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