HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-nitro-N-isopropyl-5-phenoxybenzamide → 2-amino-N-isopropyl-5-phenoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-nitro-N-isopropyl-5-phenoxybenzamide | HCID 57796898 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-amino-N-isopropyl-5-phenoxybenzamide | HCID 57796894 | 99.3% |
Reaction Steps
A solution of 34B (710 mg, 2.37 mmol) in MeOH (8 mL) was treated with 20% palladium hydroxide on carbon (110 mg). The resulting slurry was stirred under a hydrogen atmosphere for 4 hours, and then filtered through a 0.4 μm polycarbonate membrane to remove the catalyst. The filtrate was concentrated to give 34C as a white solid (636 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07569725B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-3fd0ee64b66c4f269b0a05a7fb26adca |
| Source note | uspto-grants-2009_08 |