Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethylamine → 3-chloro-4-methoxy-N-(2-{[(2-phenylethyl)amino]carbonyl}phenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethylamine | HCID 1001 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 반응물 | 2-[(3-Chloro-4-methoxybenzoyl)amino]benzoic acid | HCID 891452 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-chloro-4-methoxy-N-(2-{[(2-phenylethyl)amino]carbonyl}phenyl)benzamide | HCID 11567712 | 71.8% |
반응 단계
A solution of 42B (50 mg, 0.16 mmol) in DMF (5 mL) was treated with phenethylamine (150 μL, 1.6 mmol), diisopropylethylamine (42 mL, 0.32 mmol), and EDCI (31 mg, 0.32 mmol) at room temperature. After 2 hours Bop reagent (100 mg, 0.22 mmol) was added. After 30 minutes, the reaction was concentrated and purified by chromatography (SiO2, 30% EtOAc in hexanes) to afford 42C (47 mg, 70%). HPLC retention time: 2.79 minutes (YMC S-5 Combiscreen 4.6×50 mm, 10% to 90% MeOH/H2O w/0.2% H3PO4, 4 minute gradient).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07569725B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-f8a99551315541f5ae4c60d2fcd1b146 |
| 출처 메모 | uspto-grants-2009_08 |