Formic Acid → 2-formamido-N-isopropyl-5-phenoxybenzamide

HRID 2099977노트

반응식

HRID 2099977 반응식
[CH:1](O)=[O:2].C(OC(=O)C)(=O)C.[N+:11]([C:14]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][C:15]=1[C:16]([NH:18][CH:19]([CH3:21])[CH3:20])=[O:17])([O-])=O>C1COCC1>[CH:1]([NH:11][C:14]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][C:15]=1[C:16]([NH:18][CH:19]([CH3:21])[CH3:20])=[O:17])=[O:2]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 577968982-nitro-N-isopropyl-5-phenoxybenzamide

생성물 1

HCID 577968922-formamido-N-isopropyl-5-phenoxybenzamide수율 102.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of formic acid (0.02 mL, 0.56 mmol) and acetic anhydride (0.05 mL, 0.56 mmol) was heated to 50° C. for 2 hours under an argon atmosphere. The resulting mixture was diluted with THF (0.2 mL) and added dropwise to a solution of 34B (50 mg, 0.19 mmol) at 0° C. The reaction mixture was slowly warmed to room temperature and stirred for 16 hours. The resulting solution was concentrated to dryness and purified by chromatography (SiO2, 40% EtOAc in hexane) to afford 44A (58 mg, 100%).

후처리

  1. concentrationThe resulting solution was concentrated to dryness
  2. custompurified by chromatography (SiO2, 40% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-c1f34b6d7247481faa5773c88092142a
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569725B2

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