Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 2-[(3-chloro-4-hydroxybenzoyl)(methyl)amino]-N-isopropyl-5-phenoxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 3-chloro-4-[(3,4-dimethoxyphenyl)methoxy]-N-methyl-N-[2-[[(1-methylethyl)amino]carbonyl]-4-phenoxyphenyl]-benzamide | HCID 57796888 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[(3-chloro-4-hydroxybenzoyl)(methyl)amino]-N-isopropyl-5-phenoxybenzamide | HCID 11495865 | 68.4% |
반응 단계
A solution of 44C (30 mg, 0.05 mmol) in CH2Cl2 (1 mL) at 0° C. was treated with TFA (0.05 mL). The solution was warmed to room temperature and stirred for 16 hours. The crude mixture was purified by chromatography (SiO2, 50% EtOAc in hexane) to afford 44D (15 mg, 68%). HPLC Retention Time=3.09 min (YMC ODSA 5 u C18 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm) [M+H+]=439.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07569725B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-cdace0df7fed4bf5b36840eb8386f000 |
| 출처 메모 | uspto-grants-2009_08 |