Dichloromethane → Naphthalene-2-carboxylic acid[4-(2-hydroxycarbamoyl-vinyl)-phenyl]-amide

HRID 2100002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2100002
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]=[CH:21][C:22]([OH:24])=O)=[CH:16][CH:15]=1)=[O:12].C(Cl)Cl.Cl.[NH2:29][OH:30]>CN(C)C=O.O1CCCC1>[OH:30][NH:29][C:22]([CH:21]=[CH:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[O:12])=[CH:15][CH:16]=1)=[O:24]

Komponenten

6

Edukt 3

HCID 6344DichloromethaneHCID 443297Hydroxyamine hydrochlorideHCID 669583943-{4-[(Naphthalene-2-carbonyl)-amino]-phenyl}-acrylic acid

Produkt 1

HCID 86592260Naphthalene-2-carboxylic acid[4-(2-hydroxycarbamoyl-vinyl)-phenyl]-amideAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

(Method H8) To a suspension of 3-{4-[(naphthalene-2-carbonyl)-amino]-phenyl}-acrylic acid (5c) (0.740 g, 1.75 mmol) in methylene chloride (8 ml) oxalyl chloride (0.54 ml, 6.14 mmol) and one drop of dimethylformamide were added. The mixture was stirred for 30 min. at room temperature and for 1 hour at 40° C. Then the mixture was concentrated under reduced pressure and the residue was diluted with tetrahydrofuran (8.0 ml). In an another vessel, to a suspension of hydroxylamine hydrochloride (0.695 g, 10.0 mmol) in tetrahydrofuran (12 ml) saturated NaHCO3 solution (8.0 ml) was added and the mixture was stirred at room temperature for 5 min. The both mixtures were combined and vigorously stirred at room temperature for 30 min. The solvents were evaporated and the residue was acidified with 3% HCl to pH 5. The resulting precipitate was filtered off and washed with water (3×10 ml). The crystallization from methanol/water provided the title compound as a white solid (0.262 g, 45%). M.p. 231-233° C. 1H NMR (DMSO-d6, HMDSO) δ: 6.41 (d, 1H, J=15.8 Hz); 7.45 (d, 1H, J=15.8 Hz); 7.52-7.70 (m, 4H); 7.82-8.16 (m, 6H); 8.59 (s, 1H); 9.02 (s, 1H); 10.58 (s, 1H); 10.73 (s, 1H). HPLC analysis on Zorbax SB-C18 column: impurities <1% (column size 4.6×150 mm; mobile phase methanol×-0.1% H3PO4, gradient from 50:50 to 90:10; sample concentration 0.05 mg/ml; flow rate 1.5 ml/min.; detector UV 220 nm). Anal. Calcd for C20H16N2O3 containing 1% of inorganic impurities, %: C, 71.55; H, 4.80; N, 8.34. Found, %: C, 71.60; H, 4.78; N, 8.39.

Aufarbeitung

  1. additionwere added
  2. concentrationThen the mixture was concentrated under reduced pressure
  3. additionthe residue was diluted with tetrahydrofuran (8.0 ml)
  4. additionwas added
  5. stirringthe mixture was stirred at room temperature for 5 min
  6. stirringvigorously stirred at room temperature for 30 min
  7. customThe solvents were evaporated
  8. filtrationThe resulting precipitate was filtered off
  9. washwashed with water (3×10 ml)
  10. customThe crystallization from methanol/water

Quellen und Nachweise

ORD-Eintrag
ord-2bce0142e78f4dbfbefc8030468492a4
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07569724B2

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