Potassium Carbonate → 3-(4-Methylpiperazin-1-yl)benzene-1,2-dicarbonitrile

Participants

Reaction Steps

A mixture of 3-nitrophthalonitrile (2.121 g, 12.3 mmol), freshly dried potassium carbonate (5.45 g, 39 mmol) and N-methylpiperazine (12 mL) were heated at reflux for 2 h. The reaction mixture was poured into water (200 mL) to precipitate the product, which was filtered off and washed with water to give 5 as a beige powder (1.59 g, 54%).

Provenance & Evidence