Potassium Carbonate → 3-(4-Methylpiperazin-1-yl)benzene-1,2-dicarbonitrile

HRID 2100215Notes

Reaction equation

HRID 2100215 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=1[C:12]#[N:13])([O-])=O.C(=O)([O-])[O-].[K+].[K+].[CH3:20][N:21]1[CH2:26][CH2:25]N[CH2:23][CH2:22]1>O>[CH3:20][N:21]1[CH2:26][CH2:25][N:1]([C:4]2[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=2[C:12]#[N:13])[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 531671-MethylpiperazineHCID 1626521,2-Benzenedicarbonitrile, 3-nitro-

Product 1

HCID 577971763-(4-Methylpiperazin-1-yl)benzene-1,2-dicarbonitrileYield 54%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-nitrophthalonitrile (2.121 g, 12.3 mmol), freshly dried potassium carbonate (5.45 g, 39 mmol) and N-methylpiperazine (12 mL) were heated at reflux for 2 h. The reaction mixture was poured into water (200 mL) to precipitate the product, which was filtered off and washed with water to give 5 as a beige powder (1.59 g, 54%).

Workup

  1. temperaturewere heated
  2. temperatureat reflux for 2 h
  3. customto precipitate the product, which
  4. filtrationwas filtered off
  5. washwashed with water

Sources & evidence

ORD record
ord-ecef2fee3b4d44aa9a5fe2a9d004c84b
Source dataset
uspto-grants-2009_08
Patent number
US07572327B2

Reaction notes

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