Hydrochloric Acid → HCID 131726134, compound

HRID 2100327Notes

Reaction equation

HRID 2100327 reaction equation
[CH3:1][N:2]([S:26]([C:29]1[CH:34]=[CH:33][C:32]([CH3:35])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([N:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[CH:5][CH:4]=1.[ClH:36]>CO.CCOCC>[ClH:36].[CH3:1][N:2]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)=[CH:5][CH:4]=1)[S:26]([C:29]1[CH:34]=[CH:33][C:32]([CH3:35])=[CH:31][CH:30]=1)(=[O:27])=[O:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21864821HCID 21864821, compound2×

Product 1

HCID 131726134HCID 131726134, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

1-tert-Butyl 4-(4-{methyl[(4-methylphenyl)sulfonyl]amino}-1-naphthyl)-1-piperazinecarboxylate (intermediate 14 after reduction according to Method A) (75 mg, 0.15 mmol) was dissolved in methanol (5 mL) and treated with 1N HCl in ether (20 mL). After stirring overnight, the product precipitated and was collected by filtration, washed with ether and dried. Yield 60 mg (92%) of an off white solid.

Workup

  1. customthe product precipitated
  2. filtrationwas collected by filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-fcae8eb9281141da884a6ff60194a498
Source dataset
uspto-grants-2009_08
Patent number
US07572787B2

Reaction notes

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