1-Bromo-2,5-dichloro-3-fluorobenzene → 1-Bromo-2,5-dichloro-3-methoxybenzene

HRID 2100353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2100353
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](F)[C:3]=1[Cl:10].[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([O:12][CH3:11])[C:3]=1[Cl:10]

Komponenten

4

Edukt 2

HCID 6185131-Bromo-2,5-dichloro-3-fluorobenzeneHCID 10942334Sodium Methoxide

Produkt 1

HCID 577991361-Bromo-2,5-dichloro-3-methoxybenzeneAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Bromo-2,5-dichloro-3-fluorobenzene (40 g, 0.16 mol) and sodium methoxide (44.3 g, 0.82 mol) were stirred in methanol (500 ml) at the reflux temperature for 16 hours. The reaction was cooled to ambient temperature then quenched with water (500 ml). The mixture was extracted with diethyl ether (3×300 ml), dried (Na2SO4) and evaporated to afford the product as a white solid (40 g)

Aufarbeitung

  1. customthen quenched with water (500 ml)
  2. extractionThe mixture was extracted with diethyl ether (3×300 ml)
  3. dry with materialdried (Na2SO4)
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-97de9336ded842308d9481f2afc6c797
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572797B2

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