Sodium Hydroxide → 2-(4-(Bis(benzyloxy)phosphoryloxy)phenyl)acetic acid silver salt

HRID 2100371Notes

Reaction equation

HRID 2100371 reaction equation
[CH2:1]([O:8][P:9]([O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:22][CH:21]=1)([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[N+]([O-])([O-])=O.[Ag+:36]>O>[Ag+:36].[CH2:12]([O:11][P:9]([O:19][C:20]1[CH:21]=[CH:22][C:23]([CH2:26][C:27]([O-:29])=[O:28])=[CH:24][CH:25]=1)([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24470Silver NitrateHCID 57798931HCID 57798931, compound

Product 1

HCID 876365632-(4-(Bis(benzyloxy)phosphoryloxy)phenyl)acetic acid silver saltYield 79.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetic acid (1.5 g, 3.63 mmol) in water (50 mL) at 0° C. was added 1N NaOH slowly. The mixture was stirred at rt for 10 mins. Then AgNO3 (0.68 g, 4 mmol) was added. The reaction was stirred vigorously for 1 h in the dark. The title compound (1.5 g, 79.4% yield) was collected as a grey solid by suction filtration and dried over Drierite® under vacuum.

Workup

  1. stirringThe reaction was stirred vigorously for 1 h in the dark

Sources & evidence

ORD record
ord-085679963eb64f69a2ceb86d0985911b
Source dataset
uspto-grants-2009_08
Patent number
US07572795B2

Reaction notes

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