Sodium Hydroxide → 2-(4-(Bis(benzyloxy)phosphoryloxy)phenyl)acetic acid silver salt

Participants

Reaction Steps

To a suspension of 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetic acid (1.5 g, 3.63 mmol) in water (50 mL) at 0° C. was added 1N NaOH slowly. The mixture was stirred at rt for 10 mins. Then AgNO3 (0.68 g, 4 mmol) was added. The reaction was stirred vigorously for 1 h in the dark. The title compound (1.5 g, 79.4% yield) was collected as a grey solid by suction filtration and dried over Drierite® under vacuum.

Provenance & Evidence