tert-Butyl methyl ether → HCID 136312202, compound

Participants

Reaction Steps

(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylmethyl)-carbamic acid benzyl ester (383 mg, 1.23 mmol) in HBr (33% in acetic acid, 4 ml) was stirred for 2 h at ambient temperature. TBME (15 ml) was added and the precipitated solid was filtrated and washed with TBME to yield a salt of 2-aminomethyl-3H-pyrido[2,3-d]pyrimidin-4-one (0.1 CH3CO2H, 2.03 HBr) as white solid, MS: 176 [M+], which was subjected to the next reaction without further purification.

Provenance & Evidence