tert-Butyl methyl ether → HCID 136312202, compound

HRID 2100463Notes

Reaction equation

HRID 2100463 reaction equation
C(OC(=O)[NH:10][CH2:11][C:12]1[NH:13][C:14](=[O:22])[C:15]2[CH:21]=[CH:20][CH:19]=[N:18][C:16]=2[N:17]=1)C1C=CC=CC=1.CC(OC)(C)C>Br>[NH2:10][CH2:11][C:12]1[NH:13][C:14](=[O:22])[C:15]2[CH:21]=[CH:20][CH:19]=[N:18][C:16]=2[N:17]=1

Participants

4

Reactant 2

HCID 15413tert-Butyl methyl etherHCID 135899279HCID 135899279, compound

Product 1

HCID 136312202HCID 136312202, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylmethyl)-carbamic acid benzyl ester (383 mg, 1.23 mmol) in HBr (33% in acetic acid, 4 ml) was stirred for 2 h at ambient temperature. TBME (15 ml) was added and the precipitated solid was filtrated and washed with TBME to yield a salt of 2-aminomethyl-3H-pyrido[2,3-d]pyrimidin-4-one (0.1 CH3CO2H, 2.03 HBr) as white solid, MS: 176 [M+], which was subjected to the next reaction without further purification.

Workup

  1. filtrationthe precipitated solid was filtrated
  2. washwashed with TBME

Sources & evidence

ORD record
ord-de115649724e47aab557091fb1df4704
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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